OC-017 Autofluorescence-targeted Optical Biopsy Accurately Diagnoses Dysplasia In Barrett's Oesophagus And Can Detect The Field Of Molecular Change.
Di Pietro M., Bird-Lieberman E., Liu X., O'Donovan M., Fitzgerald R.
Probe-based confocal laser endomicroscopy (pCLE) allows optical biopsies in Barrett's oesophagus (BO) to predict histological outcome but it is subject to sampling error if performed in a random fashion. We used autofluorescence imaging (AFI) to direct pCLE and added molecular biomarkers to the histopathological diagnosis. The aims of this study were to assess the diagnostic accuracy for dysplasia of AFI-targeted optical biopsies and to investigate the correlation between pCLE patterns and field of molecular change.