Combinatorial effects of malaria season, iron deficiency, and inflammation determine plasma hepcidin concentration in African children
Atkinson SH., Armitage AE., Khandwala S., Mwangi TW., Uyoga S., Bejon PA., Williams TN., Prentice AM., Drakesmith H.
Key Points Iron status, erythropoietic drive, inflammation, and malaria season combine to control dynamic fluctuations of hepcidin in African children. At the end of the malaria season, hepcidin is low and ID is more prevalent, so iron therapy may be beneficial at this time.