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In cerebral malaria, the use of currently recommended doses of intravenous quinine may result in subtherapeutic plasma concentrations during the critical first 24 hours of treatment. A loading dose of quinine (20 mg/kg quinine dihydrochloride, equivalent to 16.7 mg/kg base, infused over 4 hours) proved a rapid and safe method of achieving plasma concentrations above the high minimum inhibitory concentrations for Plasmodium falciparum prevalent in Eastern Thailand.

Type

Journal article

Journal

Am J Trop Med Hyg

Publication Date

01/1983

Volume

32

Pages

1 - 5

Keywords

Adolescent, Adult, Brain Diseases, Female, Humans, Infusions, Parenteral, Malaria, Male, Mathematics, Plasmodium falciparum, Quinine