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While differential antibody responses SARS-CoV-2 in patients with inflammatory bowel disease (IBD) receiving infliximab and vedolizumab are well-characterized, the immune pathways underlying these differences remain unknown. Prior to COVID-19 vaccine development, we screened 235 patients with IBD receiving biological therapy for antibodies to SARS-CoV-2 and measured serum cytokines. In seropositive patients, we prospectively collected clinical data. We found a cytokine signature in patients receiving vedolizumab who are seropositive compared with seronegative for SARS-CoV-2 antibodies that may be linked to repeated SARS-CoV-2 infections. However, there were no differences between seropositive and seronegative patients receiving infliximab. In this single-center cohort of patients with IBD with anti-SARS-CoV-2 antibodies at the onset of the COVID-19 pandemic, and therefore without influence of vaccination, there is a cytokine signature in patients receiving vedolizumab but not infliximab. These findings lay the groundwork for further studies on immune consequences of viral infection in patients with IBD, which is postulated to evolve from aberrant host-microbe responses.

Original publication

DOI

10.1038/s41598-023-50035-1

Type

Journal article

Journal

Scientific reports

Publication Date

01/2024

Volume

14

Addresses

Department of Microbiology, New York University Grossman School of Medicine, New York, USA.

Keywords

ICARUS-IBD Working Group, Humans, Inflammatory Bowel Diseases, Antibodies, Viral, Cytokines, Pandemics, Antibodies, Monoclonal, Humanized, Infliximab, COVID-19, SARS-CoV-2, COVID-19 Vaccines