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Friedrich M & Pohin M & Powrie F. Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease. Immunity 2019; 50:992. 

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Our team is interested in the cellular and molecular mechanisms of chronic inflammation and fibrosis. Whilst the focus is on Inflammatory Bowel Diseases (IBDs), we aim to identify shared and distinct patho-mechanisms across organs. Combining cutting edge digital pathology and AI approaches, spatial/single-cell/bulk genomics and proteomics, highly multiplexed immunohistochemistry and flow cytometry, we profile large patient cohorts. This is complemented by mechanistic studies of in vivo disease models and in vitro organotypic tissue cultures. Current projects strive to personalise medical therapy in IBD, finding alternative treatments for fibrotic Crohn's disease, and establishing a molecular basis for symptoms in ulcerative colitis.   

Research Assistants:

Osheen Sharma (Lab Management)

Laboratory and Administrative Assistants:

Kate Hutton

Postdocs:

Simon Wölfel

Bin Li (co-supervised)

Hosuk Ryou (co-supervised)

Kristina Clark (Academic Clinical Lecturer, co-supervised)

DPhil students:

Zhi Wong (co-supervised)

Julia Pakpoor (co-supervised)

Clinical Fellows:

Khalid Shamiyah

Former lab members:

Kaiyang Song 

Rahul Ravindran

Tom Hosack