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ObjectiveThis study evaluates the experiences, perceptions, and attitudes of people with Lynch syndrome (LS) towards faecal immunochemical testing (FIT) as an adjunct to colonoscopy for colorectal cancer surveillance.MethodsA mixed-methods design included two cohorts: an emergency clinical service during the COVID-19 pandemic and a longitudinal research initiative. Paper-based surveys assessed user experiences and attitudes using Likert scales and open-ended questions. Quantitative data were analysed for response patterns, while thematic analysis explored qualitative feedback.ResultsAmong 85% of participants who rated FIT positively, 90% were confident in using the test correctly. Women reported higher anxiety (7.8%) compared with men (2.0%, p=0.045). Thematic analysis revealed gratitude for FIT's convenience during healthcare disruptions but emphasised concerns about its accuracy.ConclusionsFIT is widely perceived as an acceptable supplemental tool among surveyed people with LS, who appreciate its potential to reduce intervals between colonoscopies without compromising surveillance quality. Ongoing patient engagement is crucial to addressing concerns about FIT's reliability. Future research should evaluate long-term outcomes and explore diverse population perspectives to guide FIT implementation in LS surveillance.

Original publication

DOI

10.1136/bmjgast-2025-001751

Type

Journal article

Journal

BMJ open gastroenterology

Publication Date

05/2025

Volume

12

Addresses

King's College London, London, England, UK.

Keywords

FIT for Lynch Study Collaborators, Humans, Colorectal Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Colonoscopy, Occult Blood, Longitudinal Studies, Adult, Aged, Middle Aged, Female, Male, Early Detection of Cancer, Surveys and Questionnaires, COVID-19, SARS-CoV-2