Increasing Diagnostic Uncertainties in Children With In Utero HIV Infection.
Millar JR., Mvo Z., Bengu N., Fillis R., Sprenger K., Matthews PC., Archary M., Ndung'u T., Adland E., Puertas MC., Martinez-Picado J., Goulder P., Ucwaningo Lwabantwana Consortium Group None.
We present a case of an in utero HIV-infected child, who on day 1 of life had a positive whole blood total nucleic acid test but viral load <20 RNA copies/mL. Dried blood spot total nucleic acid testing was negative on day 1, 10 and at 3 months, while on ART prophylaxis then positive at 5 months after prophylaxis ended. Retrospective peripheral blood mononuclear cells HIV DNA testing from day 1 of life was positive, confirming in utero infection.This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.