Suppression of p21Rac Signaling and Increased Innate Immunity Mediate Remission in Crohn’s Disease
Parikh K., Zhou L., Somasundaram R., Fuhler GM., Deuring JJ., Blokzijl T., Regeling A., Kuipers EJ., Weersma RK., Nuij VJ., Alves M., Vogelaar L., Visser L., de Haar C., Krishnadath KK., van der Woude CJ., Dijkstra G., Faber KN., Peppelenbosch MP.
Overactivation of p21Rac1 is a rate-limiting step for innate immune function in Crohn’s disease and prevents remission.