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MicroRNAs (miRNAs) are small non-coding RNAs, 18-23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and regulation of the innate and adaptive immune system is discussed, with a particular focus on mechanisms pertinent to IBD and the potential translational applications.

Original publication

DOI

10.1136/gutjnl-2014-307891

Type

Journal article

Journal

Gut

Publication Date

03/2015

Volume

64

Pages

504 - 517

Keywords

CELLULAR IMMUNOLOGY, CROHN'S DISEASE, INTESTINAL TRACT, T LYMPHOCYTES, ULCERATIVE COLITIS, Adaptive Immunity, Epigenesis, Genetic, Genetic Markers, Humans, Immunity, Innate, Inflammatory Bowel Diseases, MicroRNAs