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We describe the long-term survival of an individual infected with HIV-1 during extrauterine life as a premature newborn. In the absence of viral attenuation in the Nef/LTR structure or significant co-receptor polymorphisms, slow progression was associated with the strong HIV-1-specific broadly cross-reactive CD8 T cell responses. HIV-1 infection as early as 25 weeks' gestation may thus results in the development of immune responses that control viral replication and lead to prolonged survival.


Journal article



Publication Date





2085 - 2087


Adolescent, Amino Acid Sequence, CD8-Positive T-Lymphocytes, Female, Gene Products, nef, HIV Infections, HIV Long Terminal Repeat, HIV Long-Term Survivors, HIV-1, Humans, Infant, Newborn, Infant, Premature, Diseases, Molecular Sequence Data, nef Gene Products, Human Immunodeficiency Virus