Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

This review outlines a new, personalized approach for the classification and management of airway diseases. The current approach to airways disease is, we believe, no longer fit for purpose. It is impractical, overgeneralizes complex and heterogeneous conditions and results in management that is imprecise and outcomes that are worse than they could be. Importantly, the assumptions we make when applying a diagnostic label have impeded new drug discovery and will continue to do so unless we change our approach. This review suggests a new mechanism-based approach where the emphasis is on identification of key causal mechanisms and targeted intervention with treatment based on possession of the relevant mechanism rather than an arbitrary label. We highlight several treatable traits and suggest how they can be identified and managed in different healthcare settings.

Original publication

DOI

10.1042/cs20160028

Type

Journal article

Journal

Clinical science (London, England : 1979)

Publication Date

05/2017

Volume

131

Pages

1027 - 1043

Addresses

Nuffield Department of Medicine, NDM Research Building, University of Oxford, Oxford OX3 7FZ, U.K.

Keywords

Humans, Respiratory Tract Diseases, Disease Management, Drug Discovery