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The existence and interaction of proliferating and quiescent intestinal stem cells have been debated since their discovery in the 1970s. In this issue of Cell Stem Cell, using murine intestinal organoids, Basak et al. (2017) induce stem cell quiescence by selective inhibition of EGF/MAPK signaling and define culture conditions that direct differentiation to the enteroendocrine lineage.

Original publication

DOI

10.1016/j.stem.2017.01.005

Type

Journal article

Journal

Cell stem cell

Publication Date

02/2017

Volume

20

Pages

153 - 154

Addresses

Intestinal Stem Cell Biology Laboratory, Oxford Centre for Cancer Gene Research, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK. Electronic address: simon.leedham@well.ox.ac.uk.

Keywords

Intestines, Organoids, Stem Cells, Animals, Mice, Cell Differentiation, Enteroendocrine Cells