Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Of 32 patients exposed to a single batch of factor VIII contaminated with human immunodeficiency virus (HIV), 18 became antibody positive. Serial T cell subset analyses over the succeeding four years have shown a progressive decline in circulating T4 cells in those 18 but no change in the 14 who remain seronegative. 2 of the seroconverters have died and a further 7 have symptoms attributable to HIV infection. In the group as a whole, the HLA haplotype A1 B8 DR3 was weakly associated with an increased risk of seroconversion on exposure to the virus while, in those who seroconverted, it was strongly associated with a rapid decline in T4 cells and development of HIV-related symptoms within four years of infection.

Type

Journal article

Journal

Lancet

Publication Date

28/05/1988

Volume

1

Pages

1185 - 1188

Keywords

Adult, Antibodies, Viral, Drug Contamination, Factor VIII, Follow-Up Studies, HIV, HIV Antibodies, HIV Seropositivity, HLA Antigens, HLA-A1 Antigen, HLA-B8 Antigen, HLA-D Antigens, HLA-DR Antigens, HLA-DR3 Antigen, Haplotypes, Hemophilia A, Histocompatibility Testing, Humans, Male, Middle Aged, Risk Factors, T-Lymphocytes