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A 57-year-old man developed symptoms of a respiratory tract infection which was treated with erythromycin BP. He subsequently went into acute liver failure. Investigation of a very prolonged prothrombin time revealed a marked, selective factor X deficiency (1% of normal activity). He later recovered virtually normal liver function and completely normal factor X activity.


Journal article


Postgrad Med J

Publication Date





514 - 515


Chemical and Drug Induced Liver Injury, Erythromycin, Factor X Deficiency, Humans, Hypoprothrombinemias, Male, Middle Aged, Respiratory Tract Infections