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A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13.

Original publication

DOI

10.1038/ng2061

Type

Journal article

Journal

Nat Genet

Publication Date

07/2007

Volume

39

Pages

830 - 832

Keywords

Animals, Autophagy, Case-Control Studies, Crohn Disease, GTP-Binding Proteins, Genetic Predisposition to Disease, Genetic Variation, Humans, Mice, Polymorphism, Single Nucleotide, Sequence Analysis, DNA