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Corticosteroids are of proven value for the treatment of active ulcerative colitis and Crohn's disease, but are of little value for the maintenance of remission. The development of new steroid compounds with low systemic bioavailability should allow higher doses to be given for longer periods without risking serious adverse reactions.


Journal article


Gastroenterol Clin North Am

Publication Date





21 - 34


Administration, Topical, Adrenal Cortex Hormones, Colitis, Ulcerative, Crohn Disease, Drug Administration Schedule, Enema, Humans