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Fifty patients with ulcerative colitis, intolerant of sulphasalazine, were treated with 500 mg olsalazine twice daily for a 3-month trial period. Thirty-eight of the patients (76%) tolerated the drug well, and all continued to take it beyond the 3-month period. Twelve (24%) were withdrawn because of side effects, the commonest being diarrhoea. There were no haematologic or biochemical abnormalities. Thus, olsalazine is a useful drug for patients who are intolerant of sulphasalazine.


Journal article


Scand J Gastroenterol

Publication Date





1038 - 1040


Adult, Aged, Aminosalicylic Acids, Clinical Trials as Topic, Colitis, Ulcerative, Female, Humans, Male, Middle Aged, Sulfasalazine