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Twenty patients with severe active ulcerative colitis were entered into a pilot study to test the efficacy of pulsed high-dose methylprednisolone in inducing remission. Of 20 patients, 12 improved, but 8 of 20 patients (40%) who did not went for urgent colectomy. The group proceeding to surgery tended to have more extensive disease. These results contrast unfavorably with historical control data from this unit.


Journal article


J Clin Gastroenterol

Publication Date





40 - 41


Acute Disease, Adolescent, Adult, Aged, Aged, 80 and over, Colitis, Ulcerative, Drug Administration Schedule, Female, Humans, Male, Methylprednisolone, Middle Aged, Pilot Projects