MR1 is a conserved molecule that binds microbial vitamin B metabolites and presents them to unconventional T cells. Lim and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202110125) uncover the role of AP2 in ensuring MR1 surface presentation, which relies on an atypical motif within the MR1 cytoplasmic tail.
Journal article
The Journal of cell biology
12/2022
221
Nuffield Department of Medicine, University of Oxford, Oxford, UK.
T-Lymphocytes, Humans, Vitamin B Complex, Adaptor Protein Complex 2, Histocompatibility Antigens Class I, Minor Histocompatibility Antigens, Antigen Presentation