Unconventional T cells (UTCs) play important roles in protecting barrier tissues. In this issue of Immunity, Ataide and colleagues show an additional function for these cells: populating downstream lymph nodes and skewing their cytokine profiles. This process allows tissues to adjust the function of draining lymph nodes through imprinting UTC cytokine production, subsequently influencing the immune responses that are triggered.
Journal article
Immunity
10/2022
55
1751 - 1753
University of Oxford, MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine and Nuffield Department of Medicine, Oxford, UK.