Paneth cell dysfunction and the intestinal microbiome in XIAP deficiency.

Azabdaftari A., Uhlig HH.

New data suggest how epithelial dysfunction and intestinal dysbiosis contribute to inflammatory bowel disease in patients and in models of XIAP deficiency (see the related Research Articles by Strigli et al. and Wahida et al.).

DOI

10.1126/sciimmunol.abm0293

Type

Journal article

Journal

Science immunology

Publication Date

11/2021

Volume

6

Addresses

Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford, UK.

Keywords

Paneth Cells, Lymphoproliferative Disorders, Genetic Diseases, X-Linked, Gastrointestinal Microbiome

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