Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Accept all cookies Reject all non-essential cookies Find out more

BRAF V600 mutation profiling in primary skin nodular melanoma in Indonesia: an analysis using high resolution pyrosequencing.

Rinonce HT., Aji RPM., Hayati N., Pudjohartono MF., Kameswari B., Anwar SL., Irianiwati .

ObjectiveWe aimed to investigate the prevalence and type of BRAF V600 mutations and the associations with clinicopathological variables in primary skin nodular melanoma cases in Yogyakarta and Central Java, Indonesia using pyrosequencing.ResultsBRAF V600 mutations of the V600E type were found in 21 (53.85%) specimens. The variant allele frequencies (VAFs) ranged from 5.07 to 94.70%, averaging 29.05%. However, most cases had low VAFs, with 13 (61.9%) specimens below 20% and 4 (19.05%) below 10%.

More information Original publication

DOI

10.1186/s13104-020-05000-w

Type

Journal article

Publication Date

2020-03-01T00:00:00+00:00

Volume

13

Addresses

D, e, p, a, r, t, m, e, n, t, , o, f, , A, n, a, t, o, m, i, c, a, l, , P, a, t, h, o, l, o, g, y, ,, , F, a, c, u, l, t, y, , o, f, , M, e, d, i, c, i, n, e, ,, , P, u, b, l, i, c, , H, e, a, l, t, h, ,, , a, n, d, , N, u, r, s, i, n, g, ,, , U, n, i, v, e, r, s, i, t, a, s, , G, a, d, j, a, h, , M, a, d, a, /, D, r, ., , S, a, r, d, j, i, t, o, , H, o, s, p, i, t, a, l, ,, , S, l, e, m, a, n, ,, , Y, o, g, y, a, k, a, r, t, a, ,, , 5, 5, 2, 8, 1, ,, , I, n, d, o, n, e, s, i, a, ., , h, a, n, g, g, o, r, o, _, r, i, n, o, n, c, e, @, u, g, m, ., a, c, ., i, d, .

Keywords

Humans, Melanoma, Skin Neoplasms, Proto-Oncogene Proteins B-raf, Cross-Sectional Studies, Adult, Aged, Aged, 80 and over, Middle Aged, Indonesia, Female, Male, Young Adult, High-Throughput Nucleotide Sequencing