Comprehensive, Quantitative Mapping of T Cell Epitopes in Gluten in Celiac Disease
Tye-Din JA., Stewart JA., Dromey JA., Beissbarth T., van Heel DA., Tatham A., Henderson K., Mannering SI., Gianfrani C., Jewell DP., Hill AVS., McCluskey J., Rossjohn J., Anderson RP.
Three highly immunogenic peptides from gluten are primarily responsible for celiac disease, suggesting a rational immunotherapeutic approach that could replace the need for strict, lifelong dietary gluten avoidance.