Background

I completed my clinical training at the University of East Anglia in 2016. Whilst at medical school, I was involved in clinical research within Gastroenterology specifically investigating chemoprevention of oesophageal adenocarcinoma in patients with Barrett’s oesophagus, as well as novel modalities of assessing nutritional deficit in hospital in-patients. Alongside my clinical training at the Queen Elizabeth Hospital Birmingham (2016-2018), I was also a member of the Institute of Applied Health Research at the University of Birmingham. This offered me an insight into population-based epidemiology and disease association studies in gastroenterology as well as other immune mediated inflammatory disorders. However, recent advances in single cell sequencing has shifted my focus from large scale epidemiology studies to basic science and my goal is to understand the fundamental drivers of inflammation.

As part of my DPhil, I am investigating the cellular drivers of inflammation across Crohn’s disease, ulcerative colitis and rheumatoid arthritis with a focus on identifying mechanisms behind non-response to anti-tumour necrosis factor alpha therapy.  

Research Interest

 

Publications

Thomas T*, Chandan JS*, Bhala N, Kaplan G, Siew Ng, Ghosh SGlobal Smoking Trends in Inflammatory Bowel Disease: A Systematic Review of inception cohorts”Plos One 2019 September https://doi.org/10.1371/journal.pone.0221961

Lavrentaki A*, Thomas T *, Subramanian A*, Valsamakis G, Thomas N, Toulis K, Daly B, Mastorakos G, Tahrani AA, Nirantharakumar K “Increased Risk of Non-Alcoholic Fatty Liver Disease in Women with Gestational Diabetes Mellitus: A population-based cohort study, a systematic review and a meta-analysis” Journal of Diabetes and its Complications 2019 Oct;33(10):107401.

Thomas T*, Chandan JS*, Harvey PR, Bhala N, Ghosh S, Niranthakumar K, Trudgill NJ The risk of inflammatory bowel disease in subjects presenting with perianal abscess: findings from the THIN database” Journal of Crohn’s and Colitis 2019 Apr 26;13(5):600-606

Thomas T, Chandan JS, Bhala “Unmet needs in end-of-life care for chronic liver disease” Lancet Gastroenterology & Hepatology 2019 Jan;4(1):6-7

Armstrong MJ*, Thomas T*, Iqbal T, et al “Protracted severe systemic cytomegalovirus disease in an immunosuppressed patient with ulcerative colitis” Frontline Gastroenterology (2018) Apr;9(2):143-14

Thomas T, Yoon L, Beales ILP “The impact of statins on the incidence of oesophageal cancer, particularly oesophageal adenocarcinoma: A meta-analysis”Gastrointestinal Cancer 2018 Dec;49(4):442-454.

Chandan JS, Thomas T, Gokhale KM, Bandyopadhyay S*, Taylor J*, Nirantharakumar K* “The burden of mental ill health associated with childhood maltreatment in the UK, using The Health Improvement Network database: a population-based retrospective cohort study” Lancet Psychiatry (in press)

Chandan JS, Thomas T, Bradbury-Jones C, Russell R, Bandyopadhyay S, Nirantharakumar K, Taylor J “Female survivors of intimate partner violence and risk of depression, anxiety and serious mental illness.” British Journal of Psychiatry2019 Jun 7:1-6.

Harvey PR, Thomas T, Chandan JS, Coupland B, Mytton J, Patel P, Bhala N, Niranthakumar K, Trudgill NJ “Epidemiology and mortality of achalasia in England in two national databases”Gut 2019 May;68(5):790-79

Chandan JS, Thomas T, Lee S, Marshall T, Willis B, Nirantharakumar K, Gill P "The Association between Idiopathic Thrombocytopenic Purpura (ITP) and Cardiovascular Disease (CVD): A retrospective cohort study” Journal of Thrombosis & Haemostasis. 2018 Mar;16(3):474-480

 

Harvey PR, Thomas T, Chandan JS, Nirantharakumar K, Trudgill NJ“Outcomes following feeding gastrostomy (FG) insertion in patients with learning disability”BMJ Open2019 Jun 19;9(6):e026714

Bekkali NLH, Thomas T, Murray S, Joshi D, Johnson GJ, Chapman MH, Pereira SP, Webster GJM “Preventing post-ERCP pancreatitis (PEP): the role of prophylactic pancreatic duct stenting in the rectal NSAID era” Journal of the Pancreas (2017)18(4): 316–319.

 

Player EL, Morris P, Thomas T, Vyas R, Ismail D, Tang J, Alexandre L, Forbes A “Evaluation of bioelectrical impedance analysis derived phase angle for assessment of nutrition in hospital inpatients” Clinical Nutrition 2019 Aug;38(4):1700-1706

Shivaji UN, Sharratt CL, Thomas T, Iacucci, M, Moran GW, Ghosh S, Bhala N “Managing the Adverse Events Caused by Biologics Therapy in Inflammatory Bowel Disease” Alimentary Pharmacology & Therapeutics 2019 Mar;49(6):664-680.

Randhawa R, Chandan J, Thomas T, Singh S. “An exploration of the attitudes and views of general practitioners on the use of video consultations in a primary healthcare setting: A qualitative pilot study”. Primary Health Care Research & Development (2018). Jun 18:1-7

 

Thomas T, Chandan JS “Multidisciplinary management: Inflammatory bowel disease” British Dental Journal 2017 (222), 4 - 5  

 

Chandan JS, Thomas T“The impact of Inflammatory Bowel Disease on Oral Health” British Dental Journal2017 (222), 549 - 553 

 

Chandan JS, Thomas T, Baryah HS “Anticoagulants: Updates on idarucizumab” British Dental Journal 2017 (222), 140 – 141