Sumeet Pandey, Postdoctoral Fellow 

Sumeet-rotm

Brief biography:

I received my PhD in Biochemistry working on the genetic engineering of a probiotic E. coli strain. During my PhD I received a grant to extended my studies from animal models to the human immune system in Holm Uhlig lab based at Oxford. In Oxford, initially I worked on the role of NADPH oxidase 1 in maintaining gut barrier function. My current interest is to investigate the role of anti-bacterial autophagy in the spectrum of monogenic forms of inflammatory bowel disease patient including XIAP, NOD2, CGD and NPC1. We employ small molecule inhibitors/activators and CRISPR technology to study differential autophagy pathway.

Research interests:

The role of enzymes that generate reactive oxygen species in maintaining gut barrier function

Current project(s):

Role of autophagy in monogenic forms of Inflammatory bowel disease.

sumeet presentation

Publications:

Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.

Schwerd TPandey SYang HT, et al. 

Probiotic Escherichia coli CFR 16 Producing Pyrroloquinoline Quinone (PQQ) Ameliorates 1,2-Dimethylhydrazine-Induced Oxidative Damage in Colon and Liver of Rats.

Pandey S, Singh A, Kumar P, Chaudhari A, Nareshkumar G.

Pyrroloquinoline quinone secreting probiotic Escherichia coli Nissle 1917 ameliorates ethanol induced oxidative damage and hyperlipidemia in rats.

Singh AK, Pandey SK, Naresh Kumar G.

Pyrroloquinoline quinone (PQQ) producing Escherichia coli Nissle 1917 (EcN) alleviates age associated oxidative stress and hyperlipidemia, and improves mitochondrial function in ageing rats

Singh AK, Pandey SK, Saha G, Gattupalli NK

Protection against 1,2-di-methylhydrazine-induced systemic oxidative stress and altered brain neurotransmitter status by probiotic Escherichia coli CFR 16 secreting pyrroloquinoline quinone

Pandey S, Singh A, Chaudhari N, Nampoothiri LP, Kumar GN.