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The Keshav group's research encompasses laboratory-based investigation of gastrointestinal immunity and inflammation as well as clinical studies and trials. The research is translational, aiming to use clinical investigation to understand basic mechanisms, and to take this knowledge into clinical practice. Our main interest is in understanding the mechanisms of organ-specific immunity and inflammation in the gastrointestinal tract, and particularly in determining the role of specialised epithelial cells, such as Paneth cells that maintain host defence and mediate between extrinsic micro-organisms and the innate and adaptive immune systems. Recent advances from our work includes identifying Paneth cells as potential mediators of the effect of the NOD2 gene in Crohn’s disease, and elucidating the role of the chemokine receptor CCR9 in inflammatory bowel disease.

Our team