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Alessandra Geremia

Introduction to the Geremia Group

The intestinal immune system faces the delicate task of maintaining a fine balance between regulatory and effector responses, so that tolerance is maintained against commensal bacteria and food antigens, while protective responses are mounted against pathogens.

When the host-microbial interaction is perturbed, chronic inflammatory disorders of the intestine can occur, such as inflammatory bowel disease (IBD) including Crohn’s disease (CD and Ulcerative Colitis (UC).

Our research focuses on the characterization of the mucosal immune response and the host-microbial interaction in patients with IBD and Primary Sclerosing Cholangitis (PSC).

Unfortunately, the pathogenesis of the disease is unknown and there is no curative treatment for patients. A better understanding of the mechanism involved in inflammation and increased cancer risk is needed to identify novel therapeutic strategies.

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