David G. Bonsall

david bonsal

Brief Biography: 

I have been interested in viruses since medical school and have structured the early stages of my clinical training in preparation for a career in infectious diseases. My research is focussed on viral genetics and evolution and how it can help us understand, treat and prevent diseases like viral hepatitis, zika and HIV. I believe that clinical microbial genetics will emerge as an important subspecialty to infectious diseases and as an important diagnostic service to other specialties that manage infectious pathologies.

Research interests:

I’m interested in microbial genetics, particularly of viruses. I work with a range of groups to develop methods for characterising and analysing viral genetic information using a range of next-generation sequencing methods and platforms. Most of the projects I work on are united by a clinical focus aimed at improving the effectiveness and efficiency of diagnosis and treatments in infectious diseases thus reducing some of the greatest burdens to global health

Current project:

STOPHCV: STratified medicine to Optimise the treatment of Patients with hepatitis C virus (HCV) infection

PopART Phylogenetics : A phylogenetic study of HIV transmission (and how to prevent it) in a 10,000 infected indivuals living in Zambia

Oxford Viromics: Oxford Universities pipeline for sequencing and studying clinically relevant viral pathogens.

Publications:

Ansari MA, Pedergnana V, Ip CLC, Magri A, Von Delft A, Bonsall D, Chaturvedi N, Bartha I, Smith D, Nicholson G, McVean G, Trebes A, Piazza P, J, Cooke G, Foster GR, STOP-HCV Consortium, Hudson E, McLauchlan J, Simmonds P, Bowden R, Klenerman P, Barnes E & Spencer CCA Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus (2017) Nature Genetics

Bonsall D*, Ansari MA*, Ip CL*, Trebes A, Brown A, Klenerman P, Buck D, STOP-HCV Consortium, Piazza P, Barnes E, Bowden R. ve-SEQ: Robust, unbiased enrichment for streamlined detection and whole-genome sequencing of HCV and other highly diverse pathogens (2015) F1000Research

Bonsall D, Gregory WF, Ip LCL, Donfield S, Iles J, Ansari MA, Piazza P, Trebes A, Brown A, Frater J, Pybus OG, Goulder P, Klenerman P, Bowden R, Gomperts ED, Barnes E, Kapoor A, Sharp CP, Simmonds P. Bioinformatic and laboratory screening for newly discovered viruses: viraemia frequencies and risk group associations of human hepegivirus-1 (2015) Emerging Infectious Diseases (Submitted)

Iles JC, Njouom R, Foupouapouognigni Y, Bonsall D, Bowden R, Trebes A, Piazza P, Barnes E, Pepin K, Klenerman P, Pybus OG. Characterisation of hepatitis C virus recombination in Cameroon using non-specific next generation sequencing (2015) Journal of Clinical Microbiology

Huang KH *, Bonsall D *, Katzourakis A, Thomson EC, Fidler SJ, Main J, Muir D, Weber JN, Frater AJ, Phillips RE, Pybus OG, Goulder PJ, McClure MO, Cooke GS, Klenerman P. B-cell depletion reveals a role for antibodies in the control of chronic HIV-1 infection (2010) Nature Communications

The SPARTAC Trial Investigators. Short-course antiretroviral therapy in primary HIV infection (2013) N Engl J Med

Gall A, Kaye S, Hué S, Bonsall D, Rance R, Baillie GJ, Fidler SJ, Weber JN, McClure MO, Kellam P. Restriction of V3 region sequence divergence in the HIV-1 envelope gene during antiretroviral treatment in a cohort of recent seroconverters (2013) Retrovirology

English S, Katzourakis A, Bonsall D, Flanagan P, Duda A, Fidler S, Weber J, McClure M, SPARTAC Trial Investigators, Phillips R, Frater J. Phylogenetic analysis consistent with a clinical history of sexual transmission of HIV-1 from a single donor reveals transmission of highly distinct variants (2011) Retrovirology

Pizzato M, Erlwein O, Bonsall D, Kaye S, Muir D, McClure MO. A one-step SYBR Green I-based product-enhanced reverse transcriptase assay for the quantitation of retroviruses in cell culture supernatants (2009) J Virol Methods

Bonsall D et al. A fully-automated pipeline for sequencing whole viral genomes without virus-specific PCR amplification to determine HCV resistance to antiviral therapy. (2014) Abstracts of The International Liver Congress