I have been working with the Barnes group alongside my clinical training for several years. Much of my work has been focused on translational cellular immunology in immune mediated hepatobiliary disease. Recently I have been awarded a Welcome Trust Clinical Fellowship to undertake a PhD on HBV immunotherapy within the vaccine group.
I am interested in harnessing cellular immunology to understand disease pathogenesis and develop novel treatment strategies for hepatobiliary conditions.
IgG4-Related Disease Study: Natural history and pathogenesis
Immunotherapy for chronic Hepatitis B infection
Culver EL, Smit WL, Evans C, Sadler R, Cargill T, Makuch M, et al. No evidence to support a role for Helicobacter pylori infection and plasminogen binding protein in autoimmune pancreatitis and IgG4-related disease in a UK cohort. Pancreatol Off J Int Assoc Pancreatol IAP Al. 2017 Apr 5;
Culver EL, Sadler R, Bateman AC, Makuch M, Cargill T, Ferry B, et al. Increases in IgE, Eosinophils, and Mast Cells can be Used in Diagnosis and to Predict Relapse of IgG4-related Disease. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc. 2017 Feb 18;
Culver EL, Sadler R, Simpson D, Cargill T, Makuch M, Bateman AC, et al. Elevated Serum IgG4 Levels in Diagnosis, Treatment Response, Organ Involvement, and Relapse in a Prospective IgG4-Related Disease UK Cohort. Am J Gastroenterol. 2016 May;111(5):733–43.
Culver EL, Vermeulen E, Makuch M, van Leeuwen A, Sadler R, Cargill T, et al. Increased IgG4 responses to multiple food and animal antigens indicate a polyclonal expansion and differentiation of pre-existing B cells in IgG4-related disease. Ann Rheum Dis. 2015 May;74(5):944–7.
Kumar P, Cargill T, Fellows S, Moore H. Inspiring trainees to consider a career in medical education. Med Teach. 2014 Mar;36(3):273.
Eder M, Farne H, Cargill T, Abbara A, Davidson RN. Intravenous artesunate versus intravenous quinine in the treatment of severe falciparum malaria: a retrospective evaluation from a UK centre. Pathog Glob Health. 2012 Jul;106(3):181–7.
Cargill T, Weaver TD, Patterson S. The commissioning and provision of advocacy for problem drug users in English DATS: A cross-sectional survey. Drugs Educ Prev Policy. 2012 Apr;19(2):163–70.