I am a postdoctoral scientist funded by the Wellcome Trust Senior Investigator Award project, applying variety of experimental systems and super-resolution microscopy techniques to investigate the influence of genome wide properties of RNA viruses, such as dinucleotide composition and RNA structure, on their interactions with cellular defence mechanisms, host response and evolutionary fitness.
Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7
Goonawardane N. et al, (2021), mSphere, 6
Use of a small DNA virus model to investigate mechanisms of CpG dinucleotide-induced attenuation of virus replication.
Loew L. et al, (2020), The Journal of general virology
The role of ZAP and OAS3/RNAseL pathways in the attenuation of an RNA virus with elevated frequencies of CpG and UpA dinucleotides.
Odon V. et al, (2019), Nucleic acids research, 47, 8061 - 8083
Multiple roles of the non-structural protein 3 (nsP3) alphavirus unique domain (AUD) during Chikungunya virus genome replication and transcription.
Gao Y. et al, (2019), PLoS pathogens, 15