Mathew Jones
Postdoctoral Scientist
I spent 7 years working in pharma using zebrafish as a disease model and tool for drug discovery before joining Oxford. I am currently a DPhil student in Prof Frater’s group investigating the latent reservoir in HIV-1. The core aims of my work are to:
- Identify novel markers that can be used to identify latently infected cells
- Develop a novel method to quantify the reservoir that allows viral replication competence to be determined in parallel
- Investigate whether sites of proviral integration are linked to viral rebound in the context of treatment interruption
In order to address these questions I am developing a number of novel methodologies including a water-in-oil emulsion, single-cell microfluidics platform and in-solution DNA target enrichment.
Recent publications
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Virological remission after antiretroviral therapy interruption in female African HIV seroconverters
Journal article
Gossez M. et al, (2019), AIDS, 33, 185 - 197
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Human Immunodeficiency Virus Infection Impairs Th1 and Th17 Mycobacterium tuberculosis–Specific T-Cell Responses
Journal article
Murray LW. et al, (2018), The Journal of Infectious Diseases, 217, 1782 - 1792
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Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection
Journal article
Foster C. et al, (2017), AIDS, 31, 1847 - 1851
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Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection
Journal article
Foster C. et al, (2017), AIDS, 31, 1847 - 1851
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Low copy target detection by Droplet Digital PCR through application of a novel open access bioinformatic pipeline, ‘definetherain’
Journal article
Jones M. et al, (2014), Journal of Virological Methods, 202, 46 - 53