Contact information
John Stradling
Emeritus professor of Respiratory Medicine
Obstructive sleep apnoea (OSA):-
- Epidemiology
- Cardiovascular consequences of OSA
- Diabetes/retinopathy
- Symptoms
- Clinical mangement
Current main project is a multicentre trial of CPAP in patients with OSA and diabetic macular oedema, funded by the ResMed foundation. In addition we have used a CPAP withdrawal model to look at oxidative stress in OSA, funded by British Heart Foundation. A cross-sectional study of ventilatory failure in obesity has been recently completed. The CPAP withdrawal model is being used to look at vascular reactivity in the eye and the relevance of intermittent hypoxia to the cardiovascular effects in OSA.
Recent publications
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Transcriptomics Identify a Unique Intermittent Hypoxia-mediated Profile in Obstructive Sleep Apnea
Journal article
Turnbull CD. et al, (2020), American Journal of Respiratory and Critical Care Medicine, 201, 247 - 250
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Effects of suboptimal adherence of CPAP-therapy on symptoms of obstructive sleep apnea: a randomised, double-blind, controlled trial.
Journal article
Gaisl T. et al, (2019), The European respiratory journal
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Continuous positive airway pressure versus standard care for the treatment of people with mild obstructive sleep apnoea (MERGE): a multicentre, randomised controlled trial.
Journal article
Wimms AJ. et al, (2019), The Lancet. Respiratory medicine
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The MERGE Study: The Effect of Continuous Positive Airway Pressure on Energy and Vitality in Patients with Mild Obstructive Sleep Apnea
Conference paper
Wimms A. et al, (2019), AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 199
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Effects of short-term continuous positive airway pressure withdrawal on cerebral vascular reactivity measured by blood oxygen level-dependent magnetic resonance imaging in obstructive sleep apnoea: a randomised controlled trial.
Journal article
Thiel S. et al, (2019), Eur Respir J, 53