Emeritus professor of Respiratory Medicine
Obstructive sleep apnoea (OSA):-
- Cardiovascular consequences of OSA
- Clinical mangement
Current main project is a multicentre trial of CPAP in patients with OSA and diabetic macular oedema, funded by the ResMed foundation. In addition we have used a CPAP withdrawal model to look at oxidative stress in OSA, funded by British Heart Foundation. A cross-sectional study of ventilatory failure in obesity has been recently completed. The CPAP withdrawal model is being used to look at vascular reactivity in the eye and the relevance of intermittent hypoxia to the cardiovascular effects in OSA.
Transcriptomics Identify a Unique Intermittent Hypoxia-mediated Profile in Obstructive Sleep Apnea
Turnbull CD. et al, (2020), American Journal of Respiratory and Critical Care Medicine, 201, 247 - 250
Effects of suboptimal adherence of CPAP-therapy on symptoms of obstructive sleep apnea: a randomised, double-blind, controlled trial.
Gaisl T. et al, (2019), The European respiratory journal
Continuous positive airway pressure versus standard care for the treatment of people with mild obstructive sleep apnoea (MERGE): a multicentre, randomised controlled trial.
Wimms AJ. et al, (2019), The Lancet. Respiratory medicine
The MERGE Study: The Effect of Continuous Positive Airway Pressure on Energy and Vitality in Patients with Mild Obstructive Sleep Apnea
Wimms A. et al, (2019), AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 199
Effects of short-term continuous positive airway pressure withdrawal on cerebral vascular reactivity measured by blood oxygen level-dependent magnetic resonance imaging in obstructive sleep apnoea: a randomised controlled trial.
Thiel S. et al, (2019), Eur Respir J, 53