I began my research career as an undergraduate at the University of Reading, where I specialised
in Biomedical Sciences. I then further completed a Masters in Immunology at King’s College London
(KCL), and carried out my dissertation in breast cancer research, under the supervision of
Professor Joy Burchell at Guy’s Hospital. I received my PhD degree in Immunology (2016) from
KCL, where I investigated ‘the immuno-modulatory roles of vitamin D and alpha1-antitrypsin
in human lung diseases’ in Professor Catherine Hawrylowicz’s lab. I subsequently and briefly
worked as a research associate in the Hawrylowicz lab, before joining the University of Oxford
as a postdoctoral researcher. I work with Holm Uhlig and Arian Laurence on the following projects.
-Investigating the role of transcription factor BACH2 in human T and B cells and its relationship
with colitis and common variable immune deficiency. This involves phenotypic characterisation
of new cohorts with heterozygous mutations of BACH2.
-Characterising different mutations in IL-6ST (encoding the human cytokine receptor subunit GP130)
and to investigate its impact on GP130 dependent cytokine signalling pathways including IL-6 and IL-11.
A variant in IL6ST with a selective IL-11 signaling defect in human and mouse
Schwerd T. et al, (2020), Bone Research, 8
Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance
Aschenbrenner D. et al, (2020), Gut
Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome
Béziat V. et al, (2020), Journal of Experimental Medicine, 217
Absence of GP130 cytokine receptor signaling causes extended Stüve-Wiedemann syndrome
Chen Y-H. et al, (2020), Journal of Experimental Medicine, 217
Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India.
Babji S. et al, (2020), NPJ vaccines, 5