Dominik Aschenbrenner
Postdoctoral Scientist
Research interest:
Host-microbe interactions, the regulation of pro-inflammatory immune responses and the phenotypic and functional heterogeneity of immune cells have fascinated me from the beginning of my studies in Microbiology and Genetics and continued to be the focus of my doctoral studies in Immunology and Microbiology. I joined the Uhlig Group to continue work with a strong focus on human immunology, combining cellular and molecular experimental approaches and connecting basic research with clinically translational aspects.
My research at the Translational Gastroenterology Unit is concentrated to develop a better understanding of immune mechanisms, mediators and cell types that contribute to the pathology of inflammatory bowel disease (IBD).
I am particularly interested in combining insights from studying rare disease genetics in patients with (very) early onset intestinal inflammation and common genetic variation in adult patients with IBD to study immune regulation pathways that are critical for the development of IBD and that may inform patient stratification and innovative treatment strategies for personalized medicine.
Recent publications
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A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
Journal article
Ahern DJ. et al, (2022), Cell, 185, 916 - 938.e58
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Author Correction: Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice
Journal article
Wang L. et al, (2022), Nature Genetics, 54, 213 - 213
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BCG Vaccine–Associated Complications in Patients with PTEN Hamartoma Tumor Syndrome
Journal article
Taylor H. et al, (2021), Journal of Clinical Immunology, 41, 1701 - 1705
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Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance
Journal article
Aschenbrenner D. et al, (2021), Gut, 70, 1023 - 1036
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Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice
Journal article
Wang L. et al, (2021), Nature Genetics, 53, 500 - 510