Dominik Aschenbrenner

Host-microbe interactions, the regulation of pro-inflammatory immune responses and the phenotypic and functional heterogeneity of immune cells have fascinated me from the beginning of my studies in Microbiology and Genetics and continued to be the focus of my doctoral studies in Immunology and Microbiology. I joined the Uhlig Group to continue work with a strong focus on human immunology, combining cellular and molecular experimental approaches and connecting basic research with clinically translational aspects.

My research at the Translational Gastroenterology Unit is concentrated to develop a better understanding of immune mechanisms, mediators and cell types that contribute to the pathology of inflammatory bowel disease (IBD).

I am particularly interested in combining insights from studying rare disease genetics in patients with (very) early onset intestinal inflammation and common genetic variation in adult patients with IBD to study immune regulation pathways that are critical for the development of IBD and that may inform patient stratification and innovative treatment strategies for personalized medicine.