Chantal Hargreaves
Dr
Postdoctoral Scientist
I’m interested in how genetic variation impacts on the immune system in health and disease, and how using cutting-edge genomic technologies can advance our understanding of immunodeficiency, autoimmunity and cancer.
I became interested in immunology during my undergraduate degree in Medical Sciences at the University of Birmingham. I completed my PhD at King’s College London in 2012, investigating the role of somatic hypermutation in generating autoreactive antibodies in autoimmune thyroid disease. I moved to the University of Southampton for a postdoctoral position investigating whether genetic variation at the Fc gamma receptor locus influences the success of monoclonal antibody therapy in cancer.
In 2016 I joined the lab of Dr Smita Patel at the University of Oxford as a postdoctoral scientist. My current projects include investigating the genetic basis of Common Variable Immunodeficiency Disorder using high-throughput DNA sequencing and identifying novel disrupted pathways using RNA sequencing.
Research interests
Immunodeficiency, autoimmunity, blood cancer, antibodies, B cells, genomics
Websites
Recent publications
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Journal article
Hargreaves CE. et al, (2021), J Clin Immunol
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Hussain K. et al, (2019), Front Immunol, 10
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Kienzler A-K. et al, (2017), Clin Exp Immunol, 188, 326 - 332
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Hargreaves CE. et al, (2016), PLOS ONE, 11, e0145040 - e0145040
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Hargreaves CE. et al, (2015), PLOS ONE, 10, e0142379 - e0142379
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Hargreaves CE. et al, (2015), Immunological Reviews, 268, 6 - 24
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Hussain K. et al, (2015), Blood, 125, 102 - 110
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Simmonds MJ. et al, (2014), J Clin Endocrinol Metab, 99, E127 - E131
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Hargreaves CE. et al, (2013), The Journal of Immunology, 190, 5373 - 5381
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Yesmin K. et al, (2010), Clin Endocrinol (Oxf), 73, 119 - 125