Research groups
Colleges
Angela Brueggemann
Associate Professor
The main research focus of the Brueggemann group is Streptococcus pneumoniae (the ‘pneumococcus’), a bacterium that is a major cause of diseases such as pneumonia and meningitis worldwide. Current research involves using high-throughput genotyping and whole genome sequencing techniques and unique collections of isolates to understand pneumococcal evolution, especially evolutionary changes related to antimicrobial and vaccine selective pressures. Molecular epidemiology and population biology provide the foundation for all aspects of the group’s research.
Our work has particular relevance to: i) understanding how antimicrobial resistance determinants evolve and spread; ii) long-term effectiveness of the existing pneumococcal conjugate vaccines; iii) the design of future vaccines; and iv) the development of novel antimicrobials.
Recent publications
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The global meningitis genome partnership.
Journal article
Rodgers E. et al, (2020), The Journal of infection
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Prophages and satellite prophages are widespread in Streptococcus and may play a role in pneumococcal pathogenesis.
Journal article
Rezaei Javan R. et al, (2019), Nature communications, 10
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Genomic Analyses of >3,100 Nasopharyngeal Pneumococci Revealed Significant Differences Between Pneumococci Recovered in Four Different Geographical Regions
Journal article
van Tonder AJ. et al, (2019), FRONTIERS IN MICROBIOLOGY, 10
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Vaccination of Icelandic children with the 10-valent pneumococcal vaccine leads to a significant herd effect among adults in Iceland.
Journal article
Quirk SJ. et al, (2019), Journal of clinical microbiology
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Prophages and satellite prophages are widespread among Streptococcus species and may play a role in pneumococcal pathogenesis
Journal article
Javan RR. et al, (2018)