Publications
In chronological order, most recent first.
- Correspondence on 'The 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease'
Peters RJR, Martin H, Virdee A, Fryer E, Bungay H, Rodriguez-Justo M, Chouhan M, Barnes E, Webster G, Culver EL.Ann Rheum Dis. 2020 Nov 4:annrheumdis-2020-218894. doi: 10.1136/annrheumdis-2020-218894. Online ahead of print.PMID: 33148699 - Prevalence and long-term outcome of sub-clinical primary sclerosing cholangitis in patients with ulcerative colitis.
Culver EL, Bungay HK, Betts M, Forde C, Buchel O, Manganis C, Warren BF, Cummings JF, Keshav S, Travis SPL, Chapman RW.Liver Int. 2020 Aug 25. doi: 10.1111/liv.14645. Online ahead of print.PMID: 32841490 - European Guideline on IgG4-related digestive disease - UEG and SGF evidence-based recommendations
Löhr J-M, Beuers U, Vujasinovic M, Alvaro D, Brøndum Frøkjær J, Buttgereit F, Capurso G, Culver EL, de-Madaria E, Della-Torre E, Detlefsen S, Dominguez-Muñoz E, Czubkowski P, Ewald N, Frulloni L, Gubergrits N, Guney Duman D, Hackert T, Iglesias-Garcia J, Kartalis N, Laghi A, Lammert F, Lindgren F, Okhlobystin A, Oracz G, Parniczky A, Pozzi Mucelli RM, Rebours V, Rosendahl J, Schleinitz N, Schneider A, Fh van Bommel E, Verbeke CS, Pierre Vullierme M, Witt H, UEG guideline working group.
PMID: 32552502 DOI: 10.1177/2050640620934911. United European Gastroenterology Journal, July 2020. - Review of primary sclerosing cholangitis with increased IgG4 levels
Manganis CD, Chapman RW, Culver EL.
PMID: 32684731 DOI: 10.3748/wjg.v26.i23.3126. World Journal of Gastroenterology, June 2020. - Experience from the first UK inter-regional specialist multidisciplinary meeting in the diagnosis and management of IgG4-related disease.
Goodchild G, Peters R Jr, Cargill TN, Martin H, Fadipe A, Leandro M, Bailey A, Collier J, Firmin L, Chouhan M, Rodriguez-Justo M, Sadler R, Chapman RW, Bungay H, Fryer E, David J, Luqmani R, Barnes E, Webster GJ, Culver EL.
PMID: 32414739 DOI: 10.7861/clinmed.2019-0457. Clinical Medicine, May 2020. - Divergent chemokine receptor expression and the consequence for human IgG4 B cell responses.
Unger P-P A, Lighaam LC, Vermeulen E, Kruithof S, Makuch M, Culver EL, van Bruggen R, Remmerswaal EBM, Ten Berge IJM, Emmens RW, Niessen HWM, Barnes E, Wolbink GJ, Marieke van Ham S, Rispens T.
PMID: 32289181 DOI: 10.1002/eji.201948454. European Journal of Immunology, April 2020. - Expansion of a Novel Subset of PD1+CXCR5-CD4+ T Peripheral Helper Cells in IgG4-Related Disease.
Cargill T, Barnes E, Culver E.
PMID: 31977453 DOI: 10.14309/ctg.0000000000000111. Clinical Translational Gastroenterology, January 2020. - IgG4-related disease.
Culver E, Bungay H, Fryer E, Barnes E. - The 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease
Wallace ZS, Naden RP, Chari S, Choi H, Della-Torre E, Dicaire JF, Hart PA, Inoue D, Kawano M, Khosroshahi A, Kubota K, Lanzillotta M, Okazaki K, Perugino CA, Sharma A, Saeki T, Sekiguchi H, Schleinitz N, Stone JR, Takahashi N, Umehara H, Webster G, Zen Y, Stone JH; American College of Rheumatology/European League Against Rheumatism IgG4-Related Disease Classification Criteria Working Group. Arthritis Rheumatol. 2020 Jan;72(1):7-19.
doi: 10.1002/art.41120. Epub 2019 Dec 2.PMID: 31793250
Layman summary: The recent recognition of IgG4-related disease as a distinct condition and the absence of a single diagnostic feature justifies the need for classification criteria. An international multispecialty group of 86 physicians assembled by the ACR/EULAR has described classification criteria for IgG4-RD from a cohort of 1879 subjects. It is to be used for inclusion into clinical trials and other studies – not for clinical practice – and is based on obtaining of a score of ≥ 20, calculated accross 3 steps including entry, exclusion and inclusion criteria. This classification has demonstrated excellent test performance with a sensitivity > 80% and a specificity > 90%. - The 2019 American College of Rheumatology/European League Against Rheumatism classificationcriteria for IgG4-related disease.
Wallace ZS, Naden RP, Chari S, Choi HK, Della-Torre E, Dicaire JF, Hart PA, Inoue D, Kawano M, Khosroshahi A, Lanzillotta M, Okazaki K, Perugino CA, Sharma A, Saeki T, Schleinitz N, Takahashi N, Umehara H Zen Y, Stone JH; Members of the ACR/EULAR IgG4-RD Classification Criteria Working Group.
PMID: 31796497 DOI: 10.1136/annrheumdis-2019-216561
Layman summary: The recent recognition of IgG4-related disease as a distinct condition and the absence of a single diagnostic feature justifies the need for classification criteria. An international multispecialty group of 86 physicians assembled by the ACR/EULAR has described classification criteria for IgG4-RD from a cohort of 1879 subjects. It is to be used for inclusion into clinical trials and other studies – not for clinical practice – and is based on obtaining of a score of ≥ 20, calculated accross 3 steps including entry, exclusion and inclusion criteria. This classification has demonstrated excellent test performance with a sensitivity > 80% and a specificity > 90%. - Correction: Activated T-Follicular Helper 2 Cells Are Associated With Disease Activity in IgG4-Related Sclerosing Cholangitis and Pancreatitis
Cargill T, Makuch M, Sadler R, Lighaam LC, Peters R, van Ham M, Klenerman P, Bateman A, Rispens T, Barnes E, Culver EL.
PMID: 31313691 DOI: 10.14309/ctg.0000000000000069
Layman summary: IgG4-related disease can affect organs in the abdomen including ducts in the liver (sclerosing cholangitis) and the pancreas (pancreatitis). People with these conditions often have a raised level of antibodies in the blood, known as ‘IgG4’. IgG4 antibodies are produced by immune cells, which in health act as the body’s defence system against infections. In this study we investigated a type of immune cell known to be involved in antibody production called a ‘T follicular helper cell’. We found these cells were active in the blood and in the inflamed tissue of people with IgG4-related disease compared to healthy people. Although further research is needed, these cells could be a target of therapy for IgG4-related disease in the future. - Clinical phenotypes of IgG4-related disease: an analysis of two international cross-sectional cohorts
Zachary S Wallace, Yuqing Zhang, Cory A Perugino, Ray Naden, Hyon K Choi, John H Stone for the ACR/EULAR IgG4-RD Classification Criteria Committee
PMID: 30612117 DOI: 10.1136/annrheumdis-2018-214603
Layman summary: IgG4-related disease can affect multiple organs in the body. Diagnosing IgG4-related disease can sometimes be very difficult because the symptoms can mimic other conditions, and this can delay diagnosis and treatment. This study aimed to identify people with different subtypes of IgG4-related disease based on the pattern of organs affected. It surveyed IgG4-related disease experts from across the world who submitted over 700 cases of IgG4-related disease. It found that there are four different patterns of IgG4-realting disease where the main organs affected are (i) the pancreas and liver, (ii) scaring of the blood vessels and tissues at the back of the abdomen, (iii) the head and neck or (iv) the salivary glands. Females and persons of Asian descent were more likely to have IgG4-related disease affecting the head and neck than other subtypes. Further study is needed to understand whether there are certain environmental or genetic factors that may influence the development of certain IgG4-realated disease patterns. - Clinical manifestations and long-term outcomes of IgG4-related kidney and retroperitoneal involvement in a United Kingdom IgG4-related disease cohort.
R Evans, T Cargill, G Goodchild, B Oliveira, M Rodriguez-Justo, R Pepper, J Connolly, A Salama, G Webster, E Barnes, EL Culver.
PMID: 30596168 DOI: 10.1016/j.ekir.2018.08.011
Layman summary: IgG4-related disease can affect the kidneys directly or can cause tissue scarring at the back of the abdomen which might block kidney drainage. This study looked back at patients with IgG4-related disease affecting the kidneys in two hospitals in the United Kingdom. It describes the symptoms, blood test findings and scan findings of these patients to help other doctors diagnose and treat the condition. It found that in a group of 154 people with IgG4-related disease, 28 (18%) had involvement of the kidney or tissue at the back of the abdomen. In some of these patients their kidney function deteriorated over time. The study highlights the importance of identifying and treating IgG4-related disease affecting the kidney. - The endoscopist and malignant and non-malignant biliary obstruction.
Pereira SP, Goodchild G, Webster GJM.
PMID: 28931489 DOI: 10.1016/j.bbadis.2017.09.013
Layman summary: IgG4-related disease commonly affects the bile ducts in the liver, preventing them from draining and consequently causing yellowing of the skin (jaundice). There are many conditions other than IgG4-related disease that block the bile ducts and it is important that doctors make the correct diagnosis to provide the correct treatment. One test used to find the cause of bile duct blockage is via a camera (endoscope) passed through the mouth and stomach to the site where the bile ducts enter the gut. The bile ducts can be directly visualised, samples can be taken, and the ducts can be unblocked. This article reviews recent advances in the technique of endoscopy. - Immunoglobulin G4-related sclerosing cholangitis.
Goodchild G, Pereira SP, Webster G.
PMID: 30045615 DOI: 10.3904/kjim.2018.018
Layman summary: IgG4-related disease often affects the ducts in the liver (IgG4-related sclerosing cholangitis). This article describes the current knowledge of the causes, symptoms, tests treatments and long-term outcomes of the condition. - An International, Multi-Specialty Validation Study of the IgG4-Related Disease Responder Index.
Wallace ZS, Khosroshahi A, Carruthers MD, Perugino CA, Choi H, Campochiaro C, Culver EL, Cortazar F, Della-Torre E, Ebbo M, Fernandes A, Frulloni L, Hart P, Karadag O, Kawa S, Kawano M, Kim MH, Lanzillotta M, Matsui S, Okazaki K, Ryu JH, Saeki T, Schleinitz N, Tanasa P, Umehara H, Webster G, Zhang W, Stone JH.
PMID: 29457382 PMCID: PMC6098740 [Available on 2019-08-18] DOI: 10.1002/acr.23543
Layman summary: The IgG4-responder index is a tool developed for doctors to assess the severity of IgG4-related disease in a person. It can be used over time to monitor the effectiveness of treatment. This study tested the responder index to see how reliably it could be used by different doctors assessing the same person. 26 doctors assessed 12 patient narratives using the index. 3 doctors assessed 15 patients with a new diagnosis of IgG4-related disease and followed them over time. The study found that different doctors agreed on similar scores using the index on the same patients. The score improved after treatment. This shows the IgG4-responder index is a realiable tool to assess the activity of IgG4-related disease and response to treatment. - No evidence to support a role for Helicobacter pylori infection and plasminogen binding protein in autoimmune pancreatitis and IgG4-related disease in a UK cohort.
Culver EL, Smit WL, Evans C, Sadler R, Cargill T, Makuch M, Wang LM, Ferry B, Klenerman P, Barnes E
PMID: 28412148 PMCID: PMC5459459 DOI: 10.1016/j.pan.2017.04.002
Layman summary: IgG4-related disease can often affect the pancreas. It had been suggested that a common bacterium (Helicobacter pylori) that causes inflammation and ulcers in the stomach might be linked to IgG4-related disease. In this study 55 people with IgG4-related disease were compared to 52 people with different pancreatic or liver conditions. There was no difference between in previous exposure to Helicobacter pylori nor gastric inflammation or ulcers between the two groups, suggesting this bacterium does not trigger IgG4-related disease. - Thoracic involvement in IgG4-related disease in a UK-based patient cohort.
Corcoran JP, Culver EL, Anstey RM, Talwar A, Manganis CD, Cargill TN, Hallifax RJ, Psallidas I, Rahman NM, Barnes E
PMID: 29229083 DOI: 10.1016/j.rmed.2017.10.005
Layman summary: IgG4-related disease can affect the lungs in a variety of ways. In this study, over 40% of people diagnosed with IgG4-related disease at a specialist centre had evidence of lung involvement either on scans of their chest or by the symptoms they had such as breathlessness. This study highlights to doctors the importance of recognising lung involvement in patients with IgG4-related disease so that it can be treated effectively. - Increases in IgE, Eosinophils, and Mast Cells Can be Used in Diagnosis and to Predict Relapse of IgG4-Related Disease.
Culver EL, Sadler R, Bateman AC, Makuch M, Cargill T, Ferry B, Aalberse R, Barnes E, Rispens T.
PMID: 28223204 DOI:10.1016/j.cgh.2017.02.007
Layman summary: People with IgG4-related disease sometimes also have allergic conditions. In this study, blood markers associated with allergy were assessed in a group of people newly diagnosed with IgG4-related disease. In over 50% of people an antibody called ‘IgE’, associated with allergy was raised at diagnosis and allergy associated immune cells called ‘eosinophils’ were raised in over 40% of people. Tissue biopsies taken from people with active IgG4-related disease showed allergy related cells in the inflamed regions. Taken together with other parameters, levels of IgE in the blood can be used to help diagnose patients with IgG4-related disease. - IgG4-related disease-experience of 100 consecutive cases from a specialist centre.
Bateman AC, Culver EL.
PMID: 27891673 DOI: 10.1111/his.13136
Layman summary: IgG4-related disease lead to inflammatory changes in affected organs that can be viewed under a microscope when a tissue sample is taken. These changes can be used to diagnose the condition, but sometimes other diseases cause similar appearances. This article describes 100 cases of tissue samples from patients with IgG4-related disease that were assessed by a pathologist using the ‘Boston Criteria’, to judge the likelihood of IgG4-related disease. It highlights the importance of tissue samples being used together with symptoms and imaging to make the correct diagnosis of IgG4-related disease. - IgG4-related hepatobiliary disease: an overview.
Culver EL, Chapman RW
PMID: 27625195 DOI: 10.1038/nrgastro.2016.132
Layman summary: This article is an overview of IgG4-related disease, with a particular focus on the liver and pancreas. It explains why IgG4-related disease can be difficult to diagnose because it mimics other diseases and outlines new diagnostic tests that are in development. It explains how research into the cause of the disease has advanced but treatments to fully suppress the disease are still lacking. - A rare cause of colonic thickening and lymphadenopathy.
Culver EL, Wang LM, Bungay H, Chapman RW, Collier J
PMID: 27353744 DOI: 10.1136/gutjnl-2016-311433
Layman summary: This article reports the unusual symptoms of a patient with IgG4-related disease affecting the large intestine and lymph nodes. It educates other doctors to improve their recognition of IgG4-realted disease. - Elevated Serum IgG4 Levels in Diagnosis, Treatment Response, Organ Involvement, and Relapse in a Prospective IgG4-Related Disease UK Cohort.
Culver EL, Sadler R, Simpson D, Cargill T, Makuch M, Bateman AC, Ellis AJ, Collier J, Chapman RW, Klenerman P, Barnes E, Ferry B
PMID: 27091321 DOI: 10.1038/ajg.2016.40
Layman summary: Most patients with IgG4-related disease will have a raised blood level of the protein ‘IgG4’ when they first present with symptoms. However, a raised blood IgG4 measurement can also occur in many other diseases. This study looked at all the IgG4 measurements done in a hospital over a 6-year period and followed the patients to see if they had IgG4-RD or another condition. Of all the tests that were done (over 2000 tests for over 1000 patients), IgG4 was raised in 16%. Of the patients with a raised IgG4, less than a quarter had IgG4-related disease. Over 80% of patients diagnosed with IgG4-related disease had a raised blood IgG4 level and patients with several affected organs had a much higher level. The study shows that most people with a raised blood IgG4 do not have IgG4-related disease, but very raised levels make the diagnosis of IgG4-related disease more likely. - Immunoglobulin G4(+) B-cell receptor clones distinguish immunoglobulin G 4-related disease from primary sclerosing cholangitis and biliary/pancreatic malignancies.
Doorenspleet ME, Hubers LM, Culver EL, Maillette de Buy Wenniger LJ, Klarenbeek PL, Chapman RW, Baas F, van de Graaf SF, Verheij J, van Gulik TM, Barnes E, Beuers U, de Vries N
PMID: 27015613 PMCID: PMC5017301 DOI: 10.1002/hep.28568
Layman summary: The diagnosis of IgG4-related disease can be very difficult to make. This study describes two tests to diagnosis IgG4-related disease affecting the liver or pancreas, that distinguish it from other diseases that have similar symptoms. The first test assesses immune cells called ‘B cells’ that produce the IgG4 protein in the disease. The second test compares the ratio of the protein ‘IgG4’ with the protein ‘IgG’ in the blood. If this test was performed on 100 people where 40 have IgG4-RD, the test would be positive in 39 people and 1 (3%) would not have IgG4-realted disease (false-positives). The test would be negative in 61 people and of these 2 (3%) would have IgG4-related disease (false-negatives). Although more investigation is needed, these tests could be used by doctors to help diagnose IgG4-realted disease. - Autoimmune Pancreatitis - A Riddle Wrapped in an Enigma.
Webster GJ
PMID: 27333053 DOI: 10.1159/000445234
Layman summary: This article describes IgG4-relating disease that affects the pancreas. It explains how the disease can often present with a yellowing of the skin (jaundice) and can affect other organs as well as the pancreas. It outlines the current way to diagnose the disease with a combination of symptoms, blood tests, images and tissue samples because there is no single test. It advises on treatment with steroids and other drugs that dampen down inflammation and the immune system. It warns that if left untreated, the pancreas can become damaged and this can lead to diabetes (failure to control blood sugar) and difficulties digesting fat in foods. - The role of multidisciplinary meetings for benign pancreatobiliary diseases: a tertiary centre experience.
Bekkali NLH, Murray S, Winter L, Sehgal V, Webster GJM, Chapman MH, Bandula S, Amin Z, Read S, Pereira SP, Johnson GJ.
PMID: 28839911 PMCID: PMC5558274 DOI: 10.1136/flgastro-2016-100717
Layman summary: It can often be difficult to decide on the best course of action when people have problems with the liver or pancreas. Sometimes this is because several conditions give rise to similar symptoms, blood test and imaging findings. Sometimes it is difficult to decide which treatment to give person, especially if previous treatments have not worked effectively. Multidisciplinary team meetings are when a group of expert doctors in different specialties come together and discuss such cases to make personalised management plans. This article discusses how these meetings can benefit treatment decisions. - International consensus for the treatment of autoimmune pancreatitis.
Okazaki K, Chari ST, Frulloni L, Lerch MM, Kamisawa T, Kawa S, Kim MH, Lévy P, Masamune A, Webster G, Shimosegawa T.
PMID: 28027896 DOI: 10.1016/j.pan.2016.12.003
Layman summary: This article describes guidelines for the treatment of the inflamed pancreas (autoimmune pancreatitis), decided on by a panel of international experts who reviewed the research available. The type of autoimmune pancreatitis associated with IgG4-related disease is especially difficult to treat as it often relapses. This article suggests steroids as initial treatment and discussed the dose and length of treatment time and alternative immune supressing treatments that can be used if steroids do not work. It highlights more research is needed to understand which treatments work best in autoimmune pancreatitis. - Pericardiobiliary Fistulation: A Rare Complication of Therapeutic ERCP in a Patient With IgG4-Related Sclerosing Cholangitis.
Paranandi B, Joshi D, Johnson GJ, Webster GJ
PMID: 26203452 PMCID: PMC4508954 DOI: 10.14309/crj.2015.72
Layman summary: This article describes a rare complication after a patient with IgG4-related disease had a stent put in to unblock the duct draining the liver and pancreas. The stent moved through the liver and into the sac around the heart. The stent was removed, and the patient recovered. This article increases awareness of this very rare complication. - Cerebral involvement in IgG4-related disease.
Joshi D, Jager R, Hurel S, Pereira SP, Johnson GJ, Chapman M, Fowler R, Winstanley A, Losseff N, Webster GJ
PMID: 25824063 DOI: 10.7861/clinmedicine.15-2-130
Layman summary: This article describes IgG4-related disease occurring in the brain of 3 patients, which is a rare occurrence. It describes the parts of the brain affected in these individuals and how they were diagnosed and treated. - International Consensus Guidance Statement on the Management and Treatment of IgG4-Related Disease.
Khosroshahi A, Wallace ZS, Crowe JL, Akamizu T, Azumi A, Carruthers MN, Chari ST, Della-Torre E, Frulloni L, Goto H, Hart PA, Kamisawa T, Kawa S, Kawano M, Kim MH, Kodama Y, Kubota K, Lerch MM, Löhr M, Masaki Y, Matsui S, Mimori T, Nakamura S, Nakazawa T, Ohara H, Okazaki K, Ryu JH, Saeki T, Schleinitz N, Shimatsu A, Shimosegawa T, Takahashi H, Takahira M, Tanaka A, Topazian M, Umehara H, Webster GJ, Witzig TE, Yamamoto M, Zhang W, Chiba T, Stone JH; Second International Symposium on IgG4-Related Disease. PMID: 25809420 DOI: 10.1002/art.39132
Layman summary: This article outlines the guidelines for the treatment of IgG4-related disease (affecting any organ) after a meeting of experts from several medical disciplines met to discuss the available research evidence and the way in which they locally practised. There was high agreement between experts on the ways in which IgG4-related disease should be diagnosed and that steroids should be used as the initial treatment. There was less agreement on whether other treatments were needed in most patients to control the disease in the long-term but all agreed that if disease relapse occurred, steroids should be used as treatment. It highlights that more research is needed to determine which treatments prevent relapse most effectively. - Immunoglobulin G4-related sclerosing cholangitis.
Joshi D, Webster GJ
PMID: 25179687 DOI: 10.1002/hep.27411 - New Thoughts on Immunoglobulin G4-Related Sclerosing Cholangitis.
Smit WL, Culver EL, Chapman RW
PMID: 26593290 DOI: 10.1016/j.cld.2015.08.004 - Immunoglobulin G4 related chronic sclerosing sialadenitis.
Culver EL, Hunt A, Crewe E, Shah KA, Martinez-Devesa P
PMID: 25797447 DOI: 10.1017/S0022215115000195
Layman summary: Attention is drawn to the newly described entity: IgG4-related sclerosing sialadenitis, which usually occurs in the sixth decade, with a male preponderance. An elevated IgG4 level, although not sufficient, can help for the diagnosis. A pathway for investigation of IgG4-related chronic sclerosing sialadenitis by the ENT surgeon is proposed in this article. The necessity and urgency of treatment depends on the organ involvement and the first-line treatment is corticosteroids. It is important that patients benefit from multidisciplinary management. - Increased IgG4 responses to multiple food and animal antigens indicate a polyclonal expansion and differentiation of pre-existing B cells in IgG4-related disease.
Culver EL, Vermeulen E, Makuch M, van Leeuwen A, Sadler R, Cargill T, Klenerman P, Aalberse RC, van Ham SM, Barnes E, Rispens T
PMID: 25646372 PMCID: PMC4392210 DOI: 10.1136/annrheumdis-2014-206405<
Layman summary: Is the elevated IgG4 response in IgG4-related disease causal or a reflexion of immune-regulatory mechanisms? This article investigates the possibility of the elevated IgG4 being an indirect consequence of the expansion of pre-existing IgG4-switched B cells. 24 patients with IgG4-RD, 9 with PSC and an elevated serum IgG4 and 18 healthy controls were tested against egg white and yolk, milk, banana, cat, peanut, rice and wheat antigens. The IgG4 response to several of these antigens was higher in patients with IgG4-RD than in healthy controls and higher in treatment naive compared with treatment-experienced patients. There was a strong correlation between serum IgG4 and antigen-specific responses. This study is the first to show an enhanced polyclonal IgG4 response to multiple non-infectious environmental antigens in IgG4-RD. Elevated levels of IgG4 in patients with IgG4-RD may be the result primarily of a polyclonal expansion of many IgG4 B cells irrespective of their specificity and may reflect the abnormal immunological regulation of the overall IgG4 response in the disease. - A 63-year-old man with a recurrent right-sided pleural effusion.
Corcoran JP, Culver EL, Psallidas I, Hallifax RJ, Davies SJ, Bateman AC, Barnes E, Rahman NM
PMID: 25572598 DOI: 10.1136/thoraxjnl-2014-206423 - Type 1 autoimmune pancreatitis and IgG4-related sclerosing cholangitis is associated with extrapancreatic organ failure, malignancy, and mortality in a prospective UK cohort.
Huggett MT, Culver EL, Kumar M, Hurst JM, Rodriguez-Justo M, Chapman MH, Johnson GJ, Pereira SP, Chapman RW, Webster GJ, Barnes E
PMID: 25155229 PMCID: PMC4552254 DOI: 10.1038/ajg.2014.223 - Exposure to occupational antigens might predispose to IgG4-related disease.
de Buy Wenniger LJ, Culver EL, Beuers U
PMID: 24407836 PMCID: PMC4258085 DOI: 10.1002/hep.26999
Layman summary: Chronic antigenic stimulation could underlie the elevated levels of serum IgG4 in IgG4-related disease. The investigation of the job history of IgG4-RD patients from 2 cohorts revealed 88 and 61% of manual work with chronic exposure to antigens. The rates were higher in comparison of 2 disease control cohorts of PSC patients, showing 14 and 22% of patients with a history of manual work. Chronic exposure to occupational antigens may play a role in the initiation and/or maintenance of IgG4-RD in susceptible individuals. - Serum immunoglobulin G4 and immunoglobulin G1 for distinguishing immunoglobulin G4-associated cholangitis from primary sclerosing cholangitis.
Boonstra K, Culver EL, de Buy Wenniger LM, van Heerde MJ, van Erpecum KJ, Poen AC, van Nieuwkerk KM, Spanier BW, Witteman BJ, Tuynman HA, van Geloven N, van Buuren H, Chapman RW, Barnes E, Beuers U, Ponsioen CY
PMID: 24375491 PMCID: PMC4489327 DOI: 10.1002/hep.26977 - Biliary and hepatic involvement in IgG4-related disease.
Joshi D, Webster GJ.
PMID: 25312536 DOI: 10.1111/apt.12988 - Prevention of infection caused by immunosuppressive drugs in gastroenterology.
Orlicka K, Barnes E, Culver EL
PMID: 23819020 PMCID: PMC3697844 DOI: 10.1177/2040622313485275 - Phenotypic differences between IgG4+ and IgG1+ B cells point to distinct regulation of the IgG4 response.
Lighaam LC, Vermeulen E, Bleker Td, Meijlink KJ, Aalberse RC, Barnes E, Culver EL, van Ham SM, Rispens T
PMID: 24074895 DOI: 10.1016/j.jaci.2013.07.044 - Intraduct papillary mucinous neoplasm of the pancreas: a tumour linked with IgG4-related disease.
Bateman AC1, Culver EL, Sommerlad M, Chetty R
PMID: 23596150 PMCID: PMC3850253 DOI: 10.1136/jclinpath-2013-201516 - General principles of IgG4-related disease
Emma L. Culver, Adrian C. Bateman
DOI: http://dx.doi.org/10.1016/j.mpdhp.2013.01.003 - IgG4-related disease: can non-classical histopathological features or the examination of clinically uninvolved tissues be helpful in the diagnosis.
Culver EL, Bateman AC
PMID: 22685258 DOI: 10.1136/jclinpath-2012-200932 - Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis.
Hart PA, Kamisawa T, Brugge WR, Chung JB, Culver EL, Czakó L, Frulloni L, Go VL, Gress TM, Kim MH, Kawa S, Lee KT, Lerch MM, Liao WC, Löhr M, Okazaki K, Ryu JK, Schleinitz N, Shimizu K, Shimosegawa T, Soetikno R, Webster G, Yadav D, Zen Y, Chari ST
PMID: 23232048 PMCID: PMC3862979 DOI: 10.1136/gutjnl-2012-303617 - Endoscopic diagnosis of biliary tract disease.
Kalaitzakis E, Webster GJ.
PMID: 22343346 DOI: 10.1097/MOG.0b013e328351436e - Recommendations for the nomenclature of IgG4-related disease and its individual organ systemmanifestations.
Stone JH, Khosroshahi A, Deshpande V, Chan JK, Heathcote JG, Aalberse R, Azumi A, Bloch DB, Brugge WR, Carruthers MN, Cheuk W, Cornell L, Castillo CF, Ferry JA, Forcione D, Klöppel G, Hamilos DL, Kamisawa T, Kasashima S, Kawa S, Kawano M, Masaki Y, Notohara K, Okazaki K, Ryu JK, Saeki T, Sahani D, Sato Y, Smyrk T, Stone JR, Takahira M, Umehara H, Webster G, Yamamoto M, Yi E, Yoshino T, Zamboni G, Zen Y, Chari S.
PMID: 22736240 DOI: 10.1002/art.34593
Layman summary: The Organizing Committee, consisting of 35 IgG4-RD experts, met in Boston in 2011 to discuss the terminology for this newly-emerged disease. Japanese investigators had reached a consensus to refer to it as IgG4-related disease, and the Organizing Committee approved of that term. This paper gives recommendations about general and individual organ involvement terminology. - Cholangiocarcinoma or IgG4-associated cholangitis: how feasible it is to avoid unnecessary surgical interventions?
Lytras D, Kalaitzakis E, Webster GJ, Imber CJ, Amin Z, Rodriguez-Justo M, Pereira SP, Olde Damink SW, Malagoʼ M.
PMID: 22580936 DOI: 10.1097/SLA.0b013e3182533a0a - Diagnostic and therapeutic utility of single operator peroral cholangioscopy for indeterminatebiliary lesions and bile duct stones.
Kalaitzakis E, Webster GJ, Oppong KW, Kallis Y, Vlavianos P, Huggett M, Dawwas MF, Lekharaju V, Hatfield A, Westaby D, Sturgess R.
PMID: 22433791 DOI: 10.1097/MEG.0b013e3283526fa1 - A rare cause of an ileocaecal mass and lymphadenopathy.
Culver EL, Barnes E, Delaney D, Ellis AJ, George B, Chapman RW
PMID: 21891792 DOI: 10.1136/gutjnl-2011-300838 - Systematic review: management options for primary sclerosing cholangitis and its variant forms - IgG4-associated cholangitis and overlap with autoimmune hepatitis.
Culver EL, Chapman RW
PMID: 21501198 DOI: 10.1111/j.1365-2036.2011.04658.x - Clinical profile of autoimmune pancreatitis and its histological subtypes: an international multicenter survey.
Kamisawa T, Chari ST, Giday SA, Kim MH, Chung JB, Lee KT, Werner J, Bergmann F, Lerch MM, Mayerle J, Pickartz T, Lohr M, Schneider A, Frulloni L, Webster GJ, Reddy DN, Liao WC, Wang HP, Okazaki K, Shimosegawa T, Kloeppel G, Go VL.
PMID: 21747310 DOI: 10.1097/MPA.0b013e3182258a15 - Endoscopic retrograde cholangiography does not reliably distinguish IgG4-associated cholangitis from primary sclerosing cholangitis or cholangiocarcinoma.
Kalaitzakis E, Levy M, Kamisawa T, Johnson GJ, Baron TH, Topazian MD, Takahashi N, Kanno A, Okazaki K, Egawa N, Uchida K, Sheikh K, Amin Z, Shimosegawa T, Sandanayake NS, Church NI, Chapman MH, Pereira SP, Chari S, Webster GJ.
PMID: 21699807 PMCID: PMC3246637 DOI: 10.1016/j.cgh.2011.05.019 - Review article: autoimmune pancreatitis - management of an emerging disease.
Kalaitzakis E1, Webster GJ.
PMID: 21138452 DOI: 10.1111/j.1365-2036.2010.04526.x - Endoscopic retrograde pancreatography criteria to diagnose autoimmune pancreatitis: an international multicentre study.
Sugumar A, Levy MJ, Kamisawa T, Webster GJ, Kim MH, Enders F, Amin Z, Baron TH, Chapman MH, Church NI, Clain JE, Egawa N, Johnson GJ, Okazaki K, Pearson RK, Pereira SP, Petersen BT, Read S, Sah RP, Sandanayake NS, Takahashi N, Topazian MD, Uchida K, Vege SS, Chari ST.
PMID: 21131631 DOI: 10.1136/gut.2010.207951 - Histopathologic and clinical subtypes of autoimmune pancreatitis: the Honolulu consensus document.
Chari ST1, Kloeppel G, Zhang L, Notohara K, Lerch MM, Shimosegawa T, Webster GJ; Autoimmune Pancreatitis International Cooperative Study Group (APICS).
PMID: 20562576 DOI: 10.1097/MPA.0b013e3181e4d9e5 - Autoimmune pancreatitis/IgG4-associated cholangitis and primary sclerosing cholangitis--overlapping or separate diseases?
Webster GJ1, Pereira SP, Chapman RW.
PMID: 19505739 DOI: 10.1016/j.jhep.2009.04.010 - Presentation and management of post-treatment relapse in autoimmune pancreatitis/immunoglobulin G4-associated cholangitis
Sandanayake NS, Church NI, Chapman MH, Johnson GJ, Dhar DK, Amin Z, Deheragoda MG, Novelli M, Winstanley A, Rodriguez-Justo M, Hatfield AR, Pereira SP, Webster GJ.
PMID: 19345283 DOI: 10.1016/j.cgh.2009.03.021 - Extrapancreatic manifestations in autoimmune pancreatitis.
Webster GJ, Deheregoda MG, Church NI.
PMID: 19212307 - Autoimmune pancreatitis: clinical and radiological features and objective response to steroidtherapy in a UK series.
Church NI1, Pereira SP, Deheragoda MG, Sandanayake N, Amin Z, Lees WR, Gillams A, Rodriguez-Justo M, Novelli M, Seward EW, Hatfield AR, Webster GJ.
PMID: 17894845 DOI: 10.1111/j.1572-0241.2007.01531.x - The use of immunoglobulin g4 immunostaining in diagnosing pancreatic and extrapancreatic involvement in autoimmune pancreatitis.
Deheragoda MG, Church NI, Rodriguez-Justo M, Munson P, Sandanayake N, Seward EW, Miller K, Novelli M, Hatfield AR, Pereira SP, Webster GJ.
PMID: 17702660 DOI: 10.1016/j.cgh.2007.04.023
Books and Book Chapters
- EL Culver & G Webster. Chapter 6: Clinical manifestations of type II autoimmune pancreatitis. 3rd Edition Pancreatology. In Press, March 2016.
- T Cargill, EL Culver, RW Chapman. Chapter 5: IgG4-related sclerosing cholangitis. L Forman, Eds. Primary Sclerosing Cholangitis: Current Understanding, Management, and Future Developments, 1st Edition. March 2016.
- EL Culver & G Webster. Chapter 14: IgG4-related sclerosing cholangitis. G. Hirschfield Eds. Biliary disease: from Science to Clinic, 1st Edition. Sept 2015.
- EL Culver & AC Bateman. Chapter 8: IgG4-related disease. C Probert, Eds. Recent Advances in Gastroenterology, 1st Edition. JP Medical. Aug 2013.
- S Almamari, EL Culver, RW Chapman. Chapter 5: IgG4 associated cholangitis. Carey & Lindor's Cholestatic Liver Disease, 2nd Edition. Humana Press. Sept 2013.