Luo J., Wu Y., Shrimanker R., Go S., Ye Y., Hardman C., Nahler J., Chen Y-L., Stöger L., Zeng N., Liu W., Reed L., Tolkovsky AM., Klenerman P., Ogg G., Pavord ID., Xue L.

CAPSULE SUMMARY: Out of all type-2 immune cells, only ILC2s withstand corticosteroid treatment due to a reduced pro-apoptotic machinery. The findings may advance the understanding on the mechanism in steroid-resistant diseases and facilitate the development of improved therapies.

Resistance to apoptosis underpins corticosteroid-insensitivity of group 2 innate lymphoid cells.

Luo J., Wu Y., Shrimanker R., Go S., Ye Y., Hardman C., Nahler J., Chen Y-L., Stöger L., Zeng N., Liu W., Reed L., Tolkovsky AM., Klenerman P., Ogg G., Pavord ID., Xue L.

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