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Bone Infection

The research group in the Oxford Bone Infection Research Hub conduct clinical trials and research studies in the treatment, prevention and epidemiology of bone infections

Welcome to the OxBi Hub. The aim of the Oxford Bone Infection Research Hub is to encourage collaboration between scientists, clinicians and industry to promote research in all aspects of bone infection.

 

Treatment

Previously, we have shown with the OVIVA trial that antibiotics given orally are not inferior to intravenous delivery for complex orthopaedic infections. This is better for practice, for patients and for the health economy. 

Currently, we are conducting the SOLARIO trial to see if locally implanted antibiotics with a short course of systemic antibiotics (<= 7days) are just as effective as locally implanted antibiotics with the standard course of systemic antibiotics (> 4 weeks). This may help to reduce side effects, antibiotic resistance and treatment costs.

We are also contributing to the MODIC Trial which aims to investigate the utility of a locally injected antibiotic/carrier combination in the management of selected patients with low back pain. If this proves to be effective, it may provide an additional treatment option for a common symptom which often interferes with patients’ quality of life.

 

Epidemiology

To improve outcomes for patients with Necrotising Otitis Externa (NOE), and to inform the first national guidelines for the diagnosis and treatment of this disease, we are collecting data on demographics, clinical presentation, surgical and medical management, and outcomes from patients with possible NOE for the IONOE study. 

 

Prevention

To help prevent surgical site infections, we have initiated the RIIiO trial which compares patient warming techniques used during hemiarthroplasty for hip fracture. We have completed a pilot study that has shown robust recruitment and data management strategies and that the warming methods are safe to use and equally effective. Funding is now sought to conduct an adequately powered full trial to compare the incidence of infection.

Our Researchers

Bone Infection Research Group

Recent Publications