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The Translational Gastroenterology Unit is situated in the John Radcliffe hospital. The Unit builds on excellent clinical programmes in inflammatory bowel disease and hepatology as well as cutting edge fundamental science programmes in mucosal immunology. The research laboratories are in close proximity to clinical gastroenterology and bring together scientists, clinician-scientists, and gastroenterologists with the objective of translating fundamental research in mucosal immunology into enhanced treatments for inflammatory bowel disease, liver disease, and cancer.

Clinical Research

The Oxford Gastroenterology Unit is acknowledged as one of the premier units for clinical care and research in Europe and has attracted clinical and research fellows from all over the world. The unit has a particular reputation for the clinical care of ulcerative colitis and Crohn's disease patients as well as in the management of coeliac disease, irritable bowel syndrome, nutritional support and intestinal failure, cancer, autoimmune liver disease, and viral hepatitis. In addition, we perform clinical trials of novel therapies for gastrointestinal and liver diseases.

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Fundamental and Translational Research

Research within the Translational Gastroenterology Unit involves fundamental research on cellular and molecular pathways of innate and adaptive immunity in the intestine, inflammation, and immune system-bacteria interactions. Scientific findings are applied to the study of gastrointestinal diseases including inflammatory bowel disease, chronic liver disease, and cancer. In conjunction with the careful study of clinically and genetically defined patient cohorts, these efforts help identify novel therapeutic strategies and methods for optimising current treatment protocols.

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