Rose L. Szabady
I am interested in understanding how the host immune system maintains tolerance to commensal bacteria while defending against dangerous invaders, and how pathogens subvert this defense. I received my Ph.D. in microbiology, studying intestinal pathogenic bacteria. My current research examines resolution from intestinal inflammation in mouse models of colitis, focusing on host protective mechanisms that promote restoration of intestinal homeostasis.
Th17 cells, intestinal restitution and repair, bacterial pathogenesis, intestinal microbiota.
Szabady RL, Yanta JH, Halladin DK, Schofield MJ, Welch RA. TagA is a secreted protease of Vibrio cholerae that specifically cleaves mucin glycoproteins. Microbiology. 2011 Feb;157(Pt 2):516-25.
Szabady RL, Lokuta MA, Walters KB, Huttenlocher A, Welch RA Modulation of neutrophil function by a secreted mucinase of Escherichia coli O157:H7. PLoS Pathog. 2009 Feb;5(2):e1000320. Epub 2009 Feb 27.
Peterson JH, Szabady RL, Bernstein HD. An unusual signal peptide extension inhibits the binding of bacterial presecretory proteins to the signal recognition particle, trigger factor, and the SecYEG complex. J Biol Chem. 2006 Apr 7;281(14):9038-48. Epub 2006 Feb 1.
Szabady RL, Peterson JH, Skillman KM, Bernstein HD. An unusual signal peptide facilitates late steps in the biogenesis of a bacterial autotransporter. Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):221-6. Epub 2004 Dec 22.